The American South is more than just a place on a map; it’s a feeling. It’s the sweet, syrupy drawl of a friendly “y’all,” the scent of magnolia blossoms on a humid evening, and the taste of sweet tea served on a wraparound porch. But beyond the stereotypes of Spanish moss and slow-moving afternoons lies a region bursting with vibrant, diverse, and downright thrilling destinations perfect for a weekend escape.
From the neon glow of legendary music halls to the misty, ancient peaks of the Appalachian Mountains and the sugar-white sands of the Gulf Coast, the South offers a getaway for every type of traveler. So, are you ready to trade your routine for a dose of soul, history, and world-class hospitality? Pack your bags and loosen your belt because here are the best weekend getaways the South has to offer.
27. Wilmington, North Carolina
Wilmington hugs the southeastern coast of North Carolina and gives off a real easygoing vibe. There’s a blend of gorgeous beaches, a historic downtown, and views along the river that feel almost cinematic.
Walk the Wilmington Riverwalk for shops, restaurants, and scenes of the Cape Fear River. Grab a coffee or pastry at a spot downtown—there are plenty.
Wrightsville Beach is only a short drive away. You can swim, surf, or just sprawl out in the sun and do nothing (which honestly sounds perfect sometimes).
There’s a solid lineup of craft breweries and seafood joints. History buffs can wander through old homes or peek at Civil War sites.
26. Chattanooga, Tennessee
Chattanooga sits along the Tennessee River, ringed by mountains, so you get the best of both city and nature. Take a stroll or bike ride down the Riverwalk, stop by Coolidge Park for the views, or just hang out in a local coffee shop.
If you’re up for adventure, head to Lookout Mountain or wander through Rock City Gardens. Hiking, epic views, caves—it’s all there if you want it.
The food scene? Pretty chill. There’s Southern comfort food, barbecue, and some trendier spots downtown. Whether you’re with a partner or the whole family, you’ll find something to do.
25. Tybee Island, Georgia
Tybee Island is just a quick drive from Savannah, so it’s a breeze to get to if you’re after slow vibes and sand. The beaches are wide and sandy—perfect for swimming, lounging, or just zoning out to the sound of the waves.
Grab fresh seafood at a local spot or poke around the shops. The island’s small enough that you can bike or walk pretty much everywhere.
History fans can check out the Tybee Island Light Station and Museum. You can also book a dolphin tour or just catch the sunset from the pier.
Tybee’s got this chill, friendly vibe. Couples, families, or anyone needing a laid-back beach weekend will fit right in.
24. Natchez, Mississippi
Natchez sits right on the Mississippi River and is known for its grand antebellum homes and that classic Southern welcome.
If you’re into history, you’ll find plenty of old houses and museums. Stanton Hall is open for tours, and some homes have turned into bed and breakfasts—talk about a throwback experience.
Downtown’s got little shops, cozy cafes, and some truly tasty Southern food. The sunset views from the bluffs are something you’ll want to see at least once.
And if you’re in the mood for something different, try a ghost tour. Natchez is a good place to slow down, learn a little, and just enjoy the pace of small-town life.
23. Beaufort, South Carolina
Beaufort sits on the South Carolina coast, tucked between Charleston and Savannah. This small town is all about historic homes, quiet streets, and water views.
Spanish moss hangs everywhere, making the whole place feel extra relaxed. Walk downtown, browse the shops, or grab a bite—seafood’s the obvious choice here.
The waterfront park has swings facing the river. Want a little adventure? Rent a kayak or hop on a boat tour. Or just wander past the old mansions and see what you find.
It’s easy to unwind in Beaufort. The crowd’s never too thick, beaches are close, and the food is pure Lowcountry goodness.
22. Cumberland Gap National Historical Park
Cumberland Gap National Historical Park marks the spot where Kentucky, Tennessee, and Virginia all meet. Expect rolling hills, forest trails, and views that go on forever—ideal for a weekend reset.
This park’s packed with history, tracing the route pioneers took heading west. Hike up to Tri-State Peak and stand right where the three states touch.
Explore more than 85 miles of trails, check out caves, or stop at scenic overlooks. The little town of Cumberland Gap has quirky shops, a bicycle museum, and some solid spots to eat.
It’s a quiet place for picnics and wildlife watching. Hikers, history fans, or anyone who just needs some nature—there’s plenty here.
21. Austin, Texas
Austin blends live music, good food, and outdoor hangouts in one city. Check out the funky shops on South Congress, or grab some legendary Texas barbecue. At night, there’s always a band playing somewhere. Seriously, always.
If nature’s your thing, paddle around Lady Bird Lake or walk the trails nearby. Barton Springs Pool is the spot to cool off in summer.
Want to slow it down? Try a farmers’ market or sip coffee at a little café in East Austin. You’ll find it’s easy to just hang out and take it all in.
Austin’s got a friendly energy, and you can cram your weekend with activities or just wander. There are festivals, museums, and parks everywhere. Somehow, it’s lively but never feels overwhelming.
20. Raleigh, North Carolina
If you’re into cities with lots going on, Raleigh’s a solid pick for a weekend. Check out museums like the North Carolina Museum of Art or science centers that work for all ages.
Foodies can bounce between restaurants, food trucks, and breweries all over downtown. Raleigh’s music and arts scene is growing, so you might stumble onto a band or new art show.
There’s plenty of green space too. Pullen Park is a nice spot to relax, or wander the JC Raulston Arboretum if you’re into gardens.
Raleigh feels welcoming, and getting around by car is easy. You don’t have to go far for something fun, whether you want to chill or chase a little adventure.
19. Memphis, Tennessee
Craving a weekend full of music, food, and history? Memphis is calling. Beale Street is alive with blues and rock ‘n’ roll—catch a show or just let the music find you. The energy’s real.
Graceland, Elvis Presley’s place, is a must. It’s packed with costumes, gold records, and those classic cars. The Stax Museum shows off the soul side of Memphis and its legendary artists.
Don’t skip the barbecue—try ribs or pulled pork at a local spot (everyone’s got their favorite). And if you want something quirky, check out the Peabody Ducks at the Peabody Hotel. Memphis always has something going on.
18. Destin, Florida
Destin, on Florida’s Emerald Coast, is famous for its powdery white sand and clear green water. It’s a go-to for relaxing on the beach or getting out on the water—paddleboarding, fishing, you name it.
Walk the Destin Harbor Boardwalk for food, shopping, and boat tours. The seafood is always fresh, and you can grab anything from a quick snack to a big meal.
People love the sunset cruises and dolphin tours. If you’ve got kids, there are water parks and mini golf close by.
Destin’s got a laid-back feel, so it’s easy to unwind even if you’re only there for the weekend. Do a lot, or just take it slow and watch the waves.
17. Texas Hill Country
Texas Hill Country is all rolling hills, wildflowers, and small towns. It’s a favorite for weekend escapes, and it’s not far from Austin or San Antonio, but it feels like another world.
Fredericksburg stands out for its wineries and German roots. If you’re into wine tasting or wandering cute streets, you’ll like it. Wimberley is nearby with swimming holes and art galleries for a more laid-back day.
Boerne and New Braunfels have shops, historic spots, and local eats. Kayaking the rivers or checking out a festival is a popular way to spend a day.
You can stay in a cozy cabin or splurge on a fancy resort. No matter the time of year, there are trails, views, and plenty of space to just hang with friends or family.
16. Charlottesville, Virginia
Charlottesville sits tucked against the Blue Ridge Mountains in central Virginia. You can get here pretty easily from Washington, D.C. or Richmond, so it’s ideal for a quick getaway.
History buffs can wander through Monticello, Thomas Jefferson’s old estate. The downtown area’s walkable, packed with shops, cafés, and a lively farmers’ market on weekends.
If you’re into wine, there are over 40 vineyards around. You might just want to get outside, too—lots of people head for hikes in Shenandoah National Park or stroll along scenic trails.
The food scene’s strong here, with everything from Southern comfort classics to farm-to-table spots. Into art or music? You’ll probably stumble across a live show or a quirky little gallery before you know it.
15. Louisville, Kentucky
Louisville brings a mix of Southern charm and city buzz. You’ll spot cool neighborhoods full of local shops, murals, and some of Kentucky’s best places to eat.
Take a stroll by the Ohio River or pop into one of the downtown museums. Horse racing fans, of course, know the Kentucky Derby puts this city on the map.
If you want a slower pace, Bardstown’s a short drive away with bourbon history and small-town charm. Louisville works great as a home base for day trips to hiking spots or sleepy towns nearby.
Try the famous hot browns or swing by a distillery for a bourbon tasting. There’s always something going on, whether you’re into sports, food, or just poking around new neighborhoods.
14. Hot Springs, Arkansas
Hot Springs, Arkansas keeps things relaxed, about an hour from Little Rock. You can unwind in Hot Springs National Park and soak in the warm mineral baths—it’s not called “The Spa City” for nothing.
Bathhouse Row’s worth a walk, with early 1900s buildings that feel frozen in time. Nature lovers get plenty of hiking and scenic spots close by.
Don’t skip the Hot Springs Mountain Tower for big views of the Ouachita Mountains. The town’s dotted with local restaurants and coffee shops, so you’ll eat well.
Check out a museum, peek at local art, or just kick back in the parks. Spend your weekend doing a lot or nothing at all—no one’s judging.
13. Williamsburg, Virginia
There’s plenty to do in Williamsburg, whether you love history or just want to relax. Colonial Williamsburg really brings the 18th century to life with costumed guides, old buildings, and hands-on stuff to try.
If you’re chasing thrills, Busch Gardens has coasters and shows. There are also parks and trails for biking or kayaking if you’d rather be outside.
Food-wise, you’ll find local spots serving up classic Southern dishes. After a busy day, maybe poke around some boutique shops or unwind at a brewery.
Williamsburg’s easy to explore and fits whatever pace you want—great for couples, friends, or families.
12. San Antonio, Texas
San Antonio’s got a lot packed into a weekend. The city’s a blend of culture, history, and seriously good food. You’ll want to walk the famous River Walk for eats and people-watching.
Stop by the Alamo to dig into Texas history. Art fans can wander the San Antonio Museum of Art or get lost in local galleries.
Need to unwind? Try a spa or just hang out in one of the city’s parks. Families might hit up the San Antonio Zoo or the Japanese Tea Garden for a change of pace.
If you’ve got a little extra time, drive out to the Hill Country or small towns like Fredericksburg. Wineries, hiking, and quieter scenery are just a short trip away.
11. Hilton Head Island, South Carolina
Hilton Head Island offers loads of sunshine and endless beaches. The sand feels soft under your feet, and the water stays calm—perfect for just zoning out or wandering along the shore.
There’s a bunch of things to do around here. Maybe you’ll rent a bike and hit the trails, or sample some local seafood (it’s honestly hard to resist). Golfers tend to rave about the island’s well-known courses, too.
Harbour Town’s worth checking out. It’s got these charming little shops and plenty of spots to grab a bite. If you keep your eyes open by the water, you’ll probably spot some birds or even dolphins.
Feeling restless? Savannah and Beaufort are both just a quick 30-40 minute drive away. Whether you’re visiting with family, a partner, or just on your own, Hilton Head’s got this easygoing vibe that makes you want to slow down and soak up the scenery.
10. Nashville, Tennessee
They don’t call it Music City for nothing. Nashville is an electrifying symphony of sound, where the twang of a guitar spills out of every honky-tonk on Broadway and aspiring legends perform on stages big and small. A weekend here means diving headfirst into the city’s musical soul.
Spend your nights hopping between legendary venues like Tootsie’s Orchid Lounge, and your days exploring music history at the Country Music Hall of Fame or the hallowed Ryman Auditorium. But Nashville’s hit list extends beyond music; it’s a booming foodie destination, and you simply must get a whiff of Nashville hot chicken. This city is loud, proud, and unapologetically fun.
9. Asheville, North Carolina
Nestled in the heart of the majestic Blue Ridge Mountains, Asheville is a bohemian paradise with a creative spirit and an adventurous heart. This is where you come to breathe in crisp mountain air and exhale your weekly stress. The city’s downtown is a vibrant hub of independent boutiques, world-class art galleries, and one of the most celebrated craft beer scenes in the country.
Your weekend itinerary must include a scenic drive on the stunning Blue Ridge Parkway, offering views that will genuinely take your breath away. The other can’t-miss landmark is the opulent Biltmore Estate, America’s largest home, where you can wander through grand halls and manicured gardens feeling like royalty. Asheville is the perfect blend of outdoor grit and artsy sophistication.
8. Gatlinburg, Tennessee
Welcome to the ultimate mountain playground. Sitting at the main gateway to the Great Smoky Mountains National Park, Gatlinburg is a kaleidoscope of family-friendly fun and kitschy mountain charm. This town is built for pure entertainment.
Walk across the thrilling Gatlinburg SkyBridge, the longest pedestrian suspension bridge in North America, for unparalleled views of the Smokies. Ride the scenic chairlift up to Anakeesta, a mountaintop park with ziplines, tree canopy walks, and stunning vistas. Back on the ground, the main strip is a bustling wonderland of pancake houses, quirky museums, and distilleries offering free samples of authentic Tennessee moonshine. It’s a lively, fun-filled basecamp for your mountain adventures.
7. Outer Banks, North Carolina
If your idea of a perfect weekend involves wild, windswept beaches and a sense of rugged history, the Outer Banks is calling your name. This 200-mile-long string of barrier islands feels like the edge of the world, a place where the Atlantic seems a little bigger and a little wilder. It’s a paradise for beach lovers, surfers, and anyone looking to disconnect.
Spend your days climbing the iconic black-and-white striped Bodie Island Lighthouse, exploring the site of the Wright Brothers’ first flight at Kitty Hawk, or searching for the wild horses that roam the northern beaches of Corolla. Known as the “Graveyard of the Atlantic” for its numerous shipwrecks, Outer Banks has a mysterious, untamed beauty that’s completely captivating.
6. St. Augustine, Florida
St. Augustine is the nation’s oldest continuously inhabited city and was founded by the Spanish in 1565. This means its European charm and deep-rooted history are evident everywhere you look. A weekend here feels like a trip across the Atlantic.
Wander through the narrow, cobblestone streets of the historic Colonial Quarter, where Spanish-style architecture houses charming cafes, art galleries, and unique shops. Your must-see list includes the mighty Castillo de San Marcos, a 17th-century fortress overlooking the Matanzas Bay, and a playful visit to the legendary Fountain of Youth Archeological Park. St. Augustine offers a rich, immersive historical experience paired with the sunny, laid-back atmosphere of coastal Florida, making for a truly unique getaway.
5. Gulf Shores, Alabama
For a classic sun-and-sand escape with a dose of Southern hospitality, look no further than Gulf Shores. This stretch of the Alabama coastline is famed for its 32 miles of pristine, sugar-white sand beaches and sparkling turquoise waters that rival the Caribbean. It’s the quintessential beach town, perfect for families, couples, and anyone whose primary goal is to relax with their toes in the sand.
When you’re not sunbathing or splashing in the gentle surf, you can enjoy fresh-off-the-boat seafood at lively spots like The Hangout, go fishing off the massive Gulf State Park Pier, or explore the serene nature trails of Bon Secour National Wildlife Refuge. It’s an easy, breezy, and beautiful destination.
4. New Orleans, Louisiana
There is no place on earth like New Orleans. The city’s energy is intoxicating, from the 24/7 party on Bourbon Street to the sophisticated charm of the Garden District’s historic mansions. For the true NOLA experience, spend your days exploring the antique shops and art galleries of the French Quarter, then head to Frenchmen Street at night for the most authentic live jazz clubs.
And the food! Indulge in sugar-dusted beignets at Café du Monde, slurp down a bowl of rich gumbo, and savor a perfectly dressed po’boy. New Orleans isn’t just a place you visit; it’s a place you feel.
3. Savannah, Georgia
Prepare to be completely enchanted by Savannah, a city that looks as though it was lifted from the pages of a Gothic romance novel. With its 22 park-like historic squares, streets draped in dreamy Spanish moss, and beautifully preserved architecture, Savannah is arguably one of America’s most beautiful cities.
The best way to explore is on foot, perhaps with a cocktail in hand thanks to the city’s open-container policy. Take a ghost tour to hear tales of its famously haunted past, stroll along the historic and bustling River Street, and admire the stunning Cathedral of St. John the Baptist. The city’s culinary scene is also exploding, offering everything from traditional Southern fare to innovative modern cuisine. Savannah is pure magic.
2. Great Smoky Mountains National Park
For those who need to answer the call of the wild, there is no better Southern sanctuary than the Great Smoky Mountains National Park. As the most visited national park in the United States, its reputation is well-earned. The “Smokies” get their name from the blue-tinged vapor that perpetually hangs over the ancient, rolling peaks, creating a mystical and serene atmosphere.
A weekend here is all about immersion in nature. Drive the scenic Cades Cove loop for incredible wildlife viewing opportunities (black bears are a common sight!), hike a portion of the Appalachian Trail, or trek to the top of Clingmans Dome for a 360-degree view that stretches for 100 miles on a clear day. It’s a humbling, soul-stirring escape.
1. Charleston, South Carolina
Taking the top spot, Charleston is the crown jewel of the South, a city that effortlessly blends historic grandeur, culinary excellence, and coastal charm into one perfect weekend package. This is a city that fully embraces its elegance.
Lose yourself in the South of Broad neighborhood, admiring the stately antebellum mansions and strolling along the scenic Battery. Take the quintessential photo on Rainbow Row, a stretch of pastel-colored historic homes, and explore the gaslit alleys and cobblestone streets that whisper tales of centuries past. Charleston is also a world-class food destination, home to James Beard Award-winning chefs who are redefining Lowcountry cuisine. For a weekend of pure Southern sophistication and delight, nowhere does it better than Charleston.